Ricciardi-Castagnoli Paola, Granucci Francesca
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy.
Nat Rev Immunol. 2002 Nov;2(11):881-9. doi: 10.1038/nri936.
Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.
要了解免疫系统是如何被调节以及如何对病原体作出反应，将需要采用全系统方法，因为迄今为止，对单一免疫学参数的研究尚未能够揭示免疫系统的复杂性。利用微阵列技术进行的全基因组转录分析为描述复杂的生物学现象提供了一种新方法。在这里，我们讨论全基因组方法所提供的关于先天免疫的见解及其对免疫系统复杂性解释的影响。
