Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Pediatric Clinic, Department of Pediatrics, Fondazione IRCSS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Int J Mol Sci. 2022 May 12;23(10):5409. doi: 10.3390/ijms23105409.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by relapsing eczematous injuries and severe pruritus. In the last few years, the AD prevalence has been increasing, reaching 20% in children and 10% in adults in high-income countries. Recently, the potential role of probiotics in AD prevention has generated considerable interest. As many clinical studies show, the gut microbiota is able to modulate systemic inflammatory and immune responses influencing the development of sensitization and allergy. Probiotics are used increasingly against AD. However, the molecular mechanisms underlying the probiotics mediated anti-allergic effect remain unclear and there is controversy about their efficacy. In this narrative review, we examine the actual evidence on the effect of probiotic supplementation for AD prevention in the pediatric population, discussing also the potential biological mechanisms of action in this regard.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为反复发作的湿疹样损伤和严重瘙痒。在过去的几年中，AD 的患病率一直在增加，在高收入国家，儿童的患病率达到 20%，成人的患病率达到 10%。最近，益生菌在 AD 预防中的潜在作用引起了相当大的兴趣。正如许多临床研究表明的那样，肠道微生物群能够调节全身炎症和免疫反应，影响致敏和过敏的发展。益生菌越来越多地被用于对抗 AD。然而，益生菌介导的抗过敏作用的分子机制尚不清楚，其疗效也存在争议。在这篇叙述性综述中，我们检查了益生菌补充剂在儿科人群中预防 AD 的实际效果的证据，还讨论了在这方面的潜在生物学作用机制。
