Mistry Sucharita J, Atweh George F
Department of Medicine, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA.
Mt Sinai J Med. 2002 Oct;69(5):299-304.
Stathmin is a member of a novel class of microtubule-destabilizing proteins that regulate the dynamics of microtubule polymerization and depolymerization. Stathmin promotes microtubule depolymerization during interphase and late mitosis. This microtubule depolymerizing activity of stathmin is regulated by changes in its level of phosphorylation that occur during cell cycle progression. These modifications allow it to play a critical role in the regulation of the dynamic equilibrium of microtubules during different phases of the cell cycle. Stathmin is expressed at high levels in a wide variety of human cancers. Inhibition of stathmin expression in malignant cells interferes with their orderly progression through the cell cycle and abrogates their transformed phenotype. Thus, stathmin provides an attractive molecular target for disrupting the mitotic apparatus and arresting the growth of malignant cells. In this review, we describe the current understanding of the role of stathmin in the regulation of the mitotic spindle and discuss its potential as a therapeutic target of cancer therapy.
Stathmin是一类新型微管解聚蛋白的成员，这类蛋白调节微管聚合和解聚的动力学过程。Stathmin在间期和有丝分裂后期促进微管解聚。Stathmin的这种微管解聚活性受细胞周期进程中其磷酸化水平变化的调节。这些修饰使其在细胞周期不同阶段微管动态平衡的调节中发挥关键作用。Stathmin在多种人类癌症中高表达。抑制恶性细胞中Stathmin的表达会干扰其在细胞周期中的有序进程，并消除其转化表型。因此，Stathmin为破坏有丝分裂装置和阻止恶性细胞生长提供了一个有吸引力的分子靶点。在本综述中，我们描述了目前对Stathmin在有丝分裂纺锤体调节中作用的理解，并讨论了其作为癌症治疗靶点的潜力。
