Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated.

作者信息

Chiu C-H, Su L-H, He C-C, Jaing T-H, Luo C-C, Lin T-Y

机构信息

Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan, ROC.

出版信息

Pediatr Surg Int. 2002 Sep;18(5-6):410-2. doi: 10.1007/s00383-002-0830-3. Epub 2002 Apr 25.

Intestinal perforation, a life-threatening complication of toxic megacolon (TM) following non-typhoid Salmonella infection, is relatively uncommon in infants less than 1 year of age. The situation, also found in typhoid fever, appears to be cytokine-mediated. This finding may justify immunotherapy for older children with TM associated with non-typhoid Salmonella infection in order to prevent this complication.