Papazoglou Lysimachos G, Monnet Eric, Seim Howard B
Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins 80523, USA.
Vet Surg. 2002 Nov-Dec;31(6):561-70. doi: 10.1053/jvet.2002.34666.
To determine prognostic indicators for short-term outcome and long-term survival for dogs with intrahepatic portosystemic shunts (IPSS).
Retrospective study.
Thirty-two dogs of various breeds.
Clinical data extracted from medical records of dogs with IPSS were reviewed and included gender, age at surgery, weight, preoperative packed cell volume (PCV), total plasma protein concentration (TP), albumin (ALB), serum activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP), preprandial and postprandial bile acid concentrations (pre-BA, post-BA), blood urea nitrogen (BUN), glucose concentration, band neutrophils, per-rectal nuclear scintigraphy shunt fraction, whether an angiogram was performed, shunt location at surgery, whether a partial or complete attenuation of the shunt was performed, rectal temperature at the end of surgery, and duration of surgical procedure. Follow-up was determined from visits to the veterinary teaching hospital or by telephone communications with the owner or referring veterinarian.
Median survival time was 35.68 months, and 1- and 2-year probabilities of survival were 60% and 55%, respectively. Body weight, TP, ALB, and BUN were identified as prognostic indicators for short-term outcome. PCV and TP were identified as prognostic indicators for long-term survival.
PCV and TP were identified as prognostic indicators for long-term survival, whereas body weight, TP, ALB, and BUN were identified as indicators for short-term outcome in dogs with IPSS. Shunt location at surgery did not have any effect on short-term outcome and long-term survival.
Total protein, ALB, BUN, and PCV can be used to determine prognosis of dogs with intrahepatic shunt.
确定患有肝内门体分流（IPSS）的犬短期预后和长期生存的预后指标。
回顾性研究。
32只不同品种的犬。
回顾从患有IPSS的犬的病历中提取的临床数据，包括性别、手术时年龄、体重、术前红细胞压积（PCV）、总血浆蛋白浓度（TP）、白蛋白（ALB）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）的血清活性、餐前和餐后胆汁酸浓度（餐前BA、餐后BA）、血尿素氮（BUN）、血糖浓度、带状中性粒细胞、经直肠核素闪烁扫描分流分数、是否进行血管造影、手术时分流位置、是否进行了分流的部分或完全减影、手术结束时的直肠温度以及手术持续时间。通过到兽医教学医院就诊或与主人或转诊兽医进行电话沟通来确定随访情况。
中位生存时间为35.68个月，1年和2年生存概率分别为60%和55%。体重、TP、ALB和BUN被确定为短期预后的预后指标。PCV和TP被确定为长期生存的预后指标。
PCV和TP被确定为患有IPSS的犬长期生存的预后指标，而体重、TP、ALB和BUN被确定为短期预后的指标。手术时的分流位置对短期预后和长期生存没有任何影响。
总蛋白、ALB、BUN和PCV可用于确定患有肝内分流的犬的预后。
