Irmak M Kemal, Fadillioğlu Ersin, Güleç Mukaddes, Erdoğan Hasan, Yağmurca Murat, Akyol Omer
Department of Biochemistry, Faculty of Medicine, Inonu University, 44069 Malatya, Turkey.
Cell Biochem Funct. 2002 Dec;20(4):279-83. doi: 10.1002/cbf.976.
The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation. Oxygen free radicals may play a role in mechanisms of adverse effects of EMR. This study was undertaken to investigate the influence of electromagnetic radiation of a digital GSM mobile telephone (900 MHz) on oxidant and antioxidant levels in rabbits. Adenosine deaminase, xanthine oxidase, catalase, myeloperoxidase, superoxide dismutase (SOD) and glutathione peroxidase activities as well as nitric oxide (NO) and malondialdehyde levels were measured in sera and brains of EMR-exposed and sham-exposed rabbits. Serum SOD activity increased, and serum NO levels decreased in EMR-exposed animals compared to the sham group. Other parameters were not changed in either group. This finding may indicate the possible role of increased oxidative stress in the pathophysiology of adverse effect of EMR. Decreased NO levels may also suggest a probable role of NO in the adverse effect.
关于电磁辐射（EMR）在各种细胞系统中所诱导效应的报告数量仍在不断增加。到目前为止，尚未提出令人满意的机制来解释这种辐射的生物学效应。氧自由基可能在电磁辐射的不良反应机制中起作用。本研究旨在探讨数字GSM移动电话（900 MHz）的电磁辐射对家兔体内氧化剂和抗氧化剂水平的影响。对暴露于电磁辐射和假暴露的家兔的血清和大脑进行检测，测定腺苷脱氨酶、黄嘌呤氧化酶、过氧化氢酶、髓过氧化物酶、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶的活性，以及一氧化氮（NO）和丙二醛的水平。与假暴露组相比，暴露于电磁辐射的动物血清SOD活性增加，血清NO水平降低。两组中的其他参数均未改变。这一发现可能表明氧化应激增加在电磁辐射不良反应的病理生理学中可能发挥的作用。NO水平降低也可能提示NO在不良反应中可能发挥的作用。
