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西红花苷对电磁场诱导的小鼠氧化应激及肝肾损伤的改善作用。

Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.

作者信息

Vafaei Azam, Raji Ahmad Reza, Maleki Mohsen, Zaeemi Mahdieh, Ebrahimzadeh-Bideskan Alireza

机构信息

Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Avicenna J Phytomed. 2023 Mar-Apr;13(2):200-212. doi: 10.22038/AJP.2022.21169.

DOI:10.22038/AJP.2022.21169
PMID:37333475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10274308/
Abstract

OBJECTIVE

The current study's goal was to examine how crocin affects organ damage such as damage to the kidney and liver in mice treated by 2100 MHz Electro Magnetic Field.

MATERIALS AND METHODS

The liver and kidneys of mice exposed to EMFs were used in this study to examine how crocin affected them. 24 male NMARI mice were randomly divided into 4 groups: EMF group (2100 MHZ); Crocin (Cr) group (50 mg/kg); EMF+Crocin group (2100 MHZ+50 mg/kg), and control group. The antioxidant enzymes and some serum biochemical parameters were assessed in blood samples collected after the experiment. After the animals were put to sleep, liver and kidney samples were taken for histopathological and liver samples were taken for ultrastructural analyses.

RESULTS

The serum levels of urea and creatinine, and serum activities of alanine transaminase, aspartate transaminase, and alkaline phosphatase were higher in the EMF group than the control group, and this difference was significant. When compared to the control group, the EMF group's antioxidants, (catalase and superoxide dismutase) activity were decreased. These metrics significantly improved in the EMF + Cr group when compared to the EMF group. Different pathological damages were present in the liver and kidney of the EMF group, and the liver's ultrastructure had changed. Crocin administration decrease these changes.

CONCLUSION

Crocin, an antioxidant agent, may provide defense against tissue damage brought on by EMF by reducing oxidative stress.

摘要

目的

本研究的目的是检测西红花苷对经2100兆赫电磁场处理的小鼠的肾脏和肝脏等器官损伤的影响。

材料与方法

本研究使用暴露于电磁场的小鼠的肝脏和肾脏来检测西红花苷对它们的影响。将24只雄性NMARI小鼠随机分为4组：电磁场组（2100兆赫）；西红花苷（Cr）组（50毫克/千克）；电磁场+西红花苷组（2100兆赫+50毫克/千克），以及对照组。在实验后采集的血液样本中评估抗氧化酶和一些血清生化参数。在动物处死之后，采集肝脏和肾脏样本进行组织病理学检查，并采集肝脏样本进行超微结构分析。

结果

电磁场组的血清尿素和肌酐水平以及血清丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶活性均高于对照组，且这种差异具有显著性。与对照组相比，电磁场组的抗氧化剂（过氧化氢酶和超氧化物歧化酶）活性降低。与电磁场组相比，电磁场+Cr组的这些指标有显著改善。电磁场组的肝脏和肾脏存在不同程度的病理损伤，且肝脏的超微结构发生了改变。给予西红花苷可减轻这些变化。

结论

抗氧化剂西红花苷可能通过减轻氧化应激为电磁场所致的组织损伤提供防御作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/2a13d0c3580c/AJP-13-200-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/9529409c0f9d/AJP-13-200-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/05e51d8e1ec1/AJP-13-200-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/bef173163f16/AJP-13-200-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/2a13d0c3580c/AJP-13-200-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/a2fcc40f0580/AJP-13-200-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/07b8f4576644/AJP-13-200-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/a1ea4770d324/AJP-13-200-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/25d495afe3fe/AJP-13-200-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/05e51d8e1ec1/AJP-13-200-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/bef173163f16/AJP-13-200-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b314/10274308/2a13d0c3580c/AJP-13-200-g009.jpg

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