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氧化应激与 NADPH 氧化酶：连接电磁场、阳离子通道与生物学效应。

Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects.

机构信息

Department of Biology, Section of Genetics, Cell & Developmental Biology, University of Patras, 10679 Patras, Greece.

Section of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, 26504 Athens, Greece.

出版信息

Int J Mol Sci. 2021 Sep 17;22(18):10041. doi: 10.3390/ijms221810041.

DOI:10.3390/ijms221810041
PMID:34576203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8470280/
Abstract

Electromagnetic fields (EMFs) disrupt the electrochemical balance of biological membranes, thereby causing abnormal cation movement and deterioration of the function of membrane voltage-gated ion channels. These can trigger an increase of oxidative stress (OS) and the impairment of all cellular functions, including DNA damage and subsequent carcinogenesis. In this review we focus on the main mechanisms of OS generation by EMF-sensitized NADPH oxidase (NOX), the involved OS biochemistry, and the associated key biological effects.

摘要

电磁场（EMFs）破坏生物膜的电化学平衡，从而导致异常阳离子运动和膜电压门控离子通道功能恶化。这可能引发氧化应激（OS）增加和所有细胞功能受损，包括 DNA 损伤和随后的致癌作用。在这篇综述中，我们重点关注电磁场敏化 NADPH 氧化酶（NOX）产生 OS 的主要机制、涉及的 OS 生物化学以及相关的关键生物学效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49de/8470280/fc5c7306ac9b/ijms-22-10041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49de/8470280/fc5c7306ac9b/ijms-22-10041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49de/8470280/fc5c7306ac9b/ijms-22-10041-g001.jpg

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本文引用的文献

[1]
Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health.

Int J Mol Sci. 2021-4-6

[2]
Voltage-Gated Potassium Channels as Regulators of Cell Death.

Front Cell Dev Biol. 2020-12-14

[3]
On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics.

Chem Soc Rev. 2020-9-21

[4]
Autophagy: A Player in response to Oxidative Stress and DNA Damage.

Oxid Med Cell Longev. 2019-7-29

[5]
Comparing DNA damage induced by mobile telephony and other types of man-made electromagnetic fields.

Mutat Res Rev Mutat Res. 2019-3-11

[6]
Mobile phone electromagnetic radiation affects Amyloid Precursor Protein and α-synuclein metabolism in SH-SY5Y cells.

Pathophysiology. 2019

[7]
Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate.

Free Radic Biol Med. 2018-11-17

[8]
An open quantum system approach to the radical pair mechanism.

Sci Rep. 2018-10-24

[9]
Effects of electromagnetic fields exposure on the antioxidant defense system.

J Microsc Ultrastruct. 2017

[10]
Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways.

J Biochem. 2017-2-1

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