Amoli Mahsa M, Thomson Wendy, Hajeer Ali H, Calviño Maria C, Garcia-Porrua Carlos, Ollier William E R, Gonzalez-Gay Miguel A
ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom.
J Rheumatol. 2002 Nov;29(11):2367-70.
To assess the influence of interleukin-8 (IL-8), epithelial cell-derived neutrophil-activating peptide (ENA-78), and regulated upon activation normal T cell expressed and secreted (RANTES) gene polymorphisms in the susceptibility and clinical expression of patients fulfilling classification criteria for Henoch-Schönlein purpura (HSP).
Fifty patients (25 men) from Northwest Spain with primary cutaneous vasculitis classified as HSP according to proposed criteria were studied. All patients were required to have had at least 2 years' followup. Patients and ethnically matched controls were genotyped for IL-8, ENA-78, and RANTES gene polymorphisms.
No allele or genotype differences between patients fulfilling HSP classification criteria and controls were observed for any of the chemokines. However, a significantly increased frequency of allele A of the IL-8 gene polymorphism was found in patients with HSP who developed renal manifestations compared with patients without renal involvement (p = 0.02; pcorr = 0.036). Moreover, the genotype distribution in HSP patients with and without renal involvement showed statistically significant differences (p = 0.02).
In unselected patients with cutaneous vasculitis, carriage of IL-8 allele A influences the susceptibility to renal involvement.
评估白细胞介素-8（IL-8）、上皮细胞衍生的中性粒细胞激活肽（ENA-78）以及活化正常T细胞表达和分泌调节因子（RANTES）基因多态性对符合过敏性紫癜（HSP）分类标准患者易感性和临床表型的影响。
对来自西班牙西北部的50例（25例男性）原发性皮肤血管炎患者进行研究，这些患者根据既定标准被分类为HSP。所有患者均需至少随访2年。对患者及种族匹配的对照进行IL-8、ENA-78和RANTES基因多态性的基因分型。
对于任何一种趋化因子，符合HSP分类标准的患者与对照之间均未观察到等位基因或基因型差异。然而，与无肾脏受累的HSP患者相比，出现肾脏表现的HSP患者中IL-8基因多态性的A等位基因频率显著增加（p = 0.02；校正p = 0.036）。此外，有和无肾脏受累的HSP患者的基因型分布存在统计学显著差异（p = 0.02）。
在未经过挑选的皮肤血管炎患者中，携带IL-8 A等位基因会影响肾脏受累的易感性。
