Pediatric Nephrology Department, Bakirkoy Maternity and Children Hospital, Istanbul, Turkey.
J Nephrol. 2009 Nov-Dec;22(6):726-32.
Henoch-Schönlein purpura (HSP) is a systemic vasculitis; its pathogenesis is still unknown. Oxidative stress may play a role in the pathogenesis of HSP. Paraoxonase1 (PON1) is an antioxidant enzyme. Two polymorphisms have been defined in the coding region of the PON1 gene, Q/R192 and L/M55. In the present study, we aimed to investigate the effect of PON1 gene polymorphisms on the course and renal involvement of HSP in Turkish children.
Forty-six patients with HSP were compared with 34 healthy children regarding the distribution of PON1 polymorphisms.
PON1 Q/R192 genotype distribution was 58.6% QQ, 32.6% QR and 8.8% RR in the HSP group and 14.3% QQ, 50% QR and 35.7% RR in the control group. The frequency of QQ genotype was higher in the HSP group, and the presence of QQ genotype increased the risk by 3.42-fold for developing HSP (p=0.000, Fisher exact test; odds ratio [OR] = 2.048; 95% confidence interval [95% CI], 1.396-3.00). PON1 L/M55 genotype distribution was 50% LL, 43.5% LM and 6.5% MM in the HSP group and 48% LL, 26% LM and 26% MM in the control group. The frequency of MM genotype was lower in the HSP group, and the presence of MM genotype decreased the risk by 7.38-fold for developing HSP (p=0.009, Fisher exact test; OR=7.380, 95% CI, 1.474-36.953).
PON1 polymorphisms may contribute to the pathogenesis and course of HSP, but we suggest that further investigations with larger patient groups are required to confirm our results.
过敏性紫癜（HSP）是一种系统性血管炎；其发病机制尚不清楚。氧化应激可能在 HSP 的发病机制中起作用。对氧磷酶 1（PON1）是一种抗氧化酶。PON1 基因的编码区已定义了两种多态性，即 Q/R192 和 L/M55。本研究旨在探讨 PON1 基因多态性对土耳其儿童 HSP 病程和肾脏受累的影响。
将 46 例 HSP 患儿与 34 例健康儿童进行比较，分析 PON1 基因多态性的分布。
PON1 Q/R192 基因型分布在 HSP 组中为 58.6% QQ、32.6% QR 和 8.8% RR，在对照组中为 14.3% QQ、50% QR 和 35.7% RR。HSP 组中 QQ 基因型的频率较高，存在 QQ 基因型使 HSP 的发病风险增加 3.42 倍（p=0.000，Fisher 确切检验；比值比 [OR] = 2.048；95%置信区间 [95%CI]，1.396-3.00）。PON1 L/M55 基因型分布在 HSP 组中为 50% LL、43.5% LM 和 6.5% MM，在对照组中为 48% LL、26% LM 和 26% MM。HSP 组中 MM 基因型的频率较低，存在 MM 基因型使 HSP 的发病风险降低 7.38 倍（p=0.009，Fisher 确切检验；OR=7.380，95%CI，1.474-36.953）。
PON1 多态性可能有助于 HSP 的发病机制和病程，但我们建议需要进一步进行更大患者群体的研究来证实我们的结果。
