Sakaguchi Masahiro, Oka Hiroshi, Amemoto Kanji, Honda Masahiko, Nakajima Fumitaka, Kibi Shigeko, Lee Kyowon, Shimada Mamoru, Taniguchi Kazunori, Yamamoto Norihiko
Department of Internal Medicine, Moriguchi Keijinkai Hospital.
Nihon Shokakibyo Gakkai Zasshi. 2002 Oct;99(10):1197-204.
Perforated duodenal ulcer was clinically evaluated with respect to Helicobacter pylori infection and rate of recurrence in 38 ulcer patients perforated and 154 patients with non-perforated duodenal ulcer who visited our hospital in past 5 years and 6 months. The frequency of occurrence of H. pylori-positivity was 42.1% in patients with perforated duodenal ulcer, significantly lower than that of 92.9% in patients with non-perforated lesions. This result suggests that H. pylori is hardly involved in the development of perforated duodenal ulcer. The rate of recurrence was significantly lower for perforated duodenal ulcer than for non-perforated ulcer. In particular, perforated duodenal ulcer did not recur in the group on maintenance therapy with H2-recepter antagonists. Maintenance therapy using inhibitors of gastric acid secretion seems effective for the prevention of recurrence of perforated duodenal ulcer.
对38例十二指肠溃疡穿孔患者和154例非穿孔性十二指肠溃疡患者进行了临床评估，这些患者在过去5年6个月内前来我院就诊，评估内容包括幽门螺杆菌感染情况和复发率。十二指肠溃疡穿孔患者中幽门螺杆菌阳性的发生率为42.1%，显著低于非穿孔性病变患者的92.9%。这一结果表明幽门螺杆菌几乎不参与十二指肠溃疡穿孔的发生。十二指肠溃疡穿孔的复发率显著低于非穿孔性溃疡。特别是，在使用H2受体拮抗剂维持治疗的组中，十二指肠溃疡穿孔未复发。使用胃酸分泌抑制剂进行维持治疗似乎对预防十二指肠溃疡穿孔的复发有效。
