Ardies C Murray
Northeastern Illinois University, Chicago, IL 60625, USA.
Nutr Cancer. 2002;42(2):143-57. doi: 10.1207/S15327914NC422_1.
Evidence from recent publications indicates that repeated exercise may enhance the quality of life of cancer patients. The lack of reported negative effects and the consistency of the observed benefits lead one to conclude that physical exercise may provide a low-risk therapy that can improve patients' capacity to perform activities of daily living and improve their quality of life. Repeated physical activity may attenuate the adverse effects of cancer therapy, prevent or reverse cachexia, and reduce risk for a second cancer through suppression of inflammatory responses or enhancement of insulin sensitivity, rates of protein synthesis, and anti-oxidant and phase II enzyme activities. These results most likely come about through the ability of physical exercise to attenuate a chronic inflammatory signaling process and to transiently activate the mitogen-activated protein kinase, c-Jun NH2-terminal kinase, c-Jun NH2-terminal kinase-mitogen-activated protein kinase, and nuclear factor-kappa B pathways and through its ability to enhance insulin sensitivity. Expanded molecular-based research into these areas may provide new insights into the biological mechanisms associated with cancer rehabilitation and endogenous risk.
近期出版物中的证据表明，反复锻炼可能会提高癌症患者的生活质量。未报告有负面影响以及所观察到的益处具有一致性，这使人得出结论：体育锻炼可能提供一种低风险的治疗方法，可提高患者进行日常生活活动的能力并改善其生活质量。反复进行体育活动可能会减轻癌症治疗的不良反应，预防或逆转恶病质，并通过抑制炎症反应或增强胰岛素敏感性、蛋白质合成速率以及抗氧化和II期酶活性来降低患第二种癌症的风险。这些结果很可能是通过体育锻炼减弱慢性炎症信号传导过程并短暂激活丝裂原活化蛋白激酶、c-Jun氨基末端激酶、c-Jun氨基末端激酶-丝裂原活化蛋白激酶和核因子-κB途径的能力以及增强胰岛素敏感性的能力而实现的。对这些领域进行基于分子的深入研究可能会为与癌症康复和内源性风险相关的生物学机制提供新的见解。
