Biswas L, Pal A K, Chatterjee A
Endokrinologie. 1975 Feb;64(3):299-303.
Iproniazid, a very specific monoamine oxidase inhibitor, at a dose level of 200 mg/kg body weight induced luteolysis and caused lysis of deciduomata as well as resorption of the established embryos. Exogenous replacement of prolactin, a most consistent stimulant of the endocrine functioning of corpus luteum, or progesterone absolutely reversed the adversity developed following iproniazid injection. Moreover, failure of iproniazid even at a higher dose level in the deviation of the normal sequence of pregnancy after the establishment of placental adolescence strongly tempting to suggest that iproniazid could only show its luteolytic effect when the hypothalamic-pituitary complex is exclusively involved in the maintennance of pregnancy.
异烟酰异丙肼是一种非常特异的单胺氧化酶抑制剂，以200毫克/千克体重的剂量水平可诱导黄体溶解，导致蜕膜溶解以及已着床胚胎的吸收。外源性补充催乳素（黄体内分泌功能最稳定的刺激物）或孕酮可完全逆转异烟酰异丙肼注射后产生的不良影响。此外，在胎盘发育期建立后，即使给予更高剂量水平的异烟酰异丙肼，也未能改变正常的妊娠顺序，这强烈提示异烟酰异丙肼只有在下丘脑 - 垂体复合体专门参与维持妊娠时才会发挥其黄体溶解作用。
