肝细胞核因子-4α介导过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）对H4IIE细胞中葡萄糖-6-磷酸酶催化亚基基因转录的刺激作用。
Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells.
作者信息
Boustead Jared N, Stadelmaier Beth T, Eeds Angela M, Wiebe Peter O, Svitek Christina A, Oeser James K, O'Brien Richard M
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA.
出版信息
Biochem J. 2003 Jan 1;369(Pt 1):17-22. doi: 10.1042/BJ20021382.
Abstract
It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1 alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4 alpha.
摘要
最近研究表明，腺病毒介导的过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）在肝细胞中的表达可刺激葡萄糖-6-磷酸酶催化亚基（G6Pase）基因的表达。融合基因、凝胶阻滞和染色质免疫沉淀分析相结合的结果显示，在H4IIE细胞中，PGC-1α通过G6Pase启动子上一个与肝细胞核因子-4α结合的进化保守区域介导这种刺激作用。
相似文献
1
Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells.肝细胞核因子-4α介导过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）对H4IIE细胞中葡萄糖-6-磷酸酶催化亚基基因转录的刺激作用。
Biochem J. 2003 Jan 1;369(Pt 1):17-22. doi: 10.1042/BJ20021382.
2
Transcriptional regulation of glucose-6-phosphatase catalytic subunit promoter by insulin and glucose in the carnivorous fish, Sparus aurata.胰岛素和葡萄糖对肉食性鱼类金头鲷葡萄糖-6-磷酸酶催化亚基启动子的转录调控
J Mol Endocrinol. 2004 Dec;33(3):783-95. doi: 10.1677/jme.1.01552.
3
Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha.多不饱和脂肪酰辅酶A通过调节肝细胞核因子4α的DNA结合来抑制葡萄糖-6-磷酸酶启动子活性。
J Biol Chem. 2002 May 3;277(18):15736-44. doi: 10.1074/jbc.M200971200. Epub 2002 Feb 25.
4
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1）对肝脏空腹反应的调节：糖异生中肝细胞核因子4α的需求。
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4012-7. doi: 10.1073/pnas.0730870100. Epub 2003 Mar 21.
5
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.小鼠和人类葡萄糖-6-磷酸酶催化亚基基因启动子之间的序列变异导致过氧化物酶体增殖物激活受体γ共激活因子-1α的差异性激活。
Diabetologia. 2008 Aug;51(8):1505-14. doi: 10.1007/s00125-008-1050-8. Epub 2008 Jun 19.
6
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）通过激活核受体FXR来调节甘油三酯代谢。
Genes Dev. 2004 Jan 15;18(2):157-69. doi: 10.1101/gad.1138104. Epub 2004 Jan 16.
7
Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha.短链脂肪酸对培养的肝细胞和H4IIE细胞中葡萄糖-6-磷酸酶基因表达的调控：肝细胞核因子-4α的作用
J Biol Chem. 2003 Oct 17;278(42):40694-701. doi: 10.1074/jbc.M303182200. Epub 2003 Aug 11.
8
Hepatocyte nuclear factor 1alpha is an accessory factor required for activation of glucose-6-phosphatase gene transcription by glucocorticoids.肝细胞核因子1α是糖皮质激素激活葡萄糖-6-磷酸酶基因转录所需的辅助因子。
DNA Cell Biol. 1998 Nov;17(11):967-74. doi: 10.1089/dna.1998.17.967.
9
Transcription and replication of a natural hepatitis B virus nucleocapsid promoter variant is regulated in vivo by peroxisome proliferators.天然乙型肝炎病毒核衣壳启动子变体的转录和复制在体内受过氧化物酶体增殖剂调控。
Virology. 2001 Oct 25;289(2):239-51. doi: 10.1006/viro.2001.1169.
10
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription.肝细胞核因子-1作为一种辅助因子，可增强胰岛素对小鼠葡萄糖-6-磷酸酶基因转录的抑制作用。
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9208-13. doi: 10.1073/pnas.95.16.9208.
引用本文的文献
1
PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice.过氧化物酶体增殖物激活受体α 的激活部分驱动肝特异性 Hnf4a 敲除小鼠的非酒精性脂肪性肝病的发生。
J Biochem. 2023 Apr 26;173(5):393-411. doi: 10.1093/jb/mvad005.
2
Transcriptional coactivator NT-PGC-1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis.转录共激活因子NT-PGC-1α促进糖异生基因表达并增强肝脏糖异生作用。
Physiol Rep. 2016 Oct;4(20). doi: 10.14814/phy2.13013.
3
Regulation of Glucose Homeostasis by Glucocorticoids.糖皮质激素对葡萄糖稳态的调节
Adv Exp Med Biol. 2015;872:99-126. doi: 10.1007/978-1-4939-2895-8_5.
4
Inhibitory Effects of Chung Hun Wha Dam Tang (CHWDT) on High-Fat Diet-Induced Obesity via AMP-Activated Protein Kinase Activation.钟根堂减肥汤通过激活 AMP 激活的蛋白激酶抑制高脂肪饮食诱导的肥胖。
Evid Based Complement Alternat Med. 2012;2012:652473. doi: 10.1155/2012/652473. Epub 2012 Aug 29.
5
Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice.过氧化物酶体增殖物激活受体α负责在禁食和 db/db 小鼠中上调肝葡萄糖-6-磷酸酶基因的表达。
J Biol Chem. 2011 Jan 14;286(2):1157-64. doi: 10.1074/jbc.M110.157875. Epub 2010 Nov 16.
6
Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice.急性运动通过抑制胰岛素抵抗小鼠的 Foxo1/HNF-4alpha 通路来减少肝葡萄糖生成。
J Physiol. 2010 Jun 15;588(Pt 12):2239-53. doi: 10.1113/jphysiol.2009.183996. Epub 2010 Apr 26.
7
Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin.糖皮质激素和胰岛素对丙酮酸脱氢酶激酶同工酶 4（PDK4）基因表达的调节。
Mol Cell Endocrinol. 2010 Feb 5;315(1-2):159-67. doi: 10.1016/j.mce.2009.08.011. Epub 2009 Aug 22.
8
Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.胰岛素和表皮生长因子通过重叠但不同的机制抑制基础葡萄糖-6-磷酸酶催化亚基基因转录。
Biochem J. 2009 Jan 15;417(2):611-20. doi: 10.1042/BJ20080999.
9
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.小鼠和人类葡萄糖-6-磷酸酶催化亚基基因启动子之间的序列变异导致过氧化物酶体增殖物激活受体γ共激活因子-1α的差异性激活。
Diabetologia. 2008 Aug;51(8):1505-14. doi: 10.1007/s00125-008-1050-8. Epub 2008 Jun 19.
10
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.妊娠晚期慢性低血糖上调胎儿绵羊肝脏中磷酸烯醇式丙酮酸羧激酶（PEPCK），同时伴有过氧化物酶体增殖物激活受体γ共激活因子1α（PGC1α）mRNA增加和磷酸化的环磷腺苷效应元件结合蛋白（CREB）增加。
Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E365-70. doi: 10.1152/ajpendo.00639.2007. Epub 2007 Dec 4.
本文引用的文献
1
Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.一种编码普遍表达的葡萄糖-6-磷酸酶催化亚基相关蛋白的人类cDNA和基因的鉴定与表征。
J Mol Endocrinol. 2002 Oct;29(2):205-22. doi: 10.1677/jme.0.0290205.
2
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.PGC - 1基因的一种遗传变异可能导致胰岛素抵抗和II型糖尿病易感性。
Diabetologia. 2002 May;45(5):740-3. doi: 10.1007/s00125-002-0803-z. Epub 2002 Apr 23.
3
The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB).辅激活因子PGC-1通过环磷酸腺苷（cAMP）与肝细胞核因子4α（HNF4α）及环磷酸腺苷反应元件结合蛋白（CREB）协同作用，参与肝脏肉碱棕榈酰转移酶I基因表达的调控。
J Biol Chem. 2002 Oct 11;277(41):37991-8000. doi: 10.1074/jbc.M205087200. Epub 2002 Jul 9.
4
Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex.I型糖原贮积病：葡萄糖-6-磷酸酶复合物紊乱症
Curr Mol Med. 2002 Mar;2(2):121-43. doi: 10.2174/1566524024605798.
5
The glucose-6-phosphatase system.葡萄糖-6-磷酸酶系统。
Biochem J. 2002 Mar 15;362(Pt 3):513-32. doi: 10.1042/0264-6021:3620513.
6
Dissecting the transcriptional network of pancreatic islets during development and differentiation.剖析胰腺胰岛在发育和分化过程中的转录网络。
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14189-91. doi: 10.1073/pnas.251558998.
7
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.过氧化物酶体增殖物激活受体γ共激活因子1β（PGC-1β），一种与宿主细胞因子相关的新型PGC-1相关转录共激活因子。
J Biol Chem. 2002 Jan 18;277(3):1645-8. doi: 10.1074/jbc.C100631200. Epub 2001 Nov 30.
8
The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.肝细胞核因子1α和胰腺十二指肠同源盒基因1在pdx-1基因转录调控中的作用
J Biol Chem. 2001 Dec 21;276(51):47775-84. doi: 10.1074/jbc.M109244200. Epub 2001 Oct 5.
9
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.CREB 通过辅激活因子 PGC-1 调节肝脏糖异生。
Nature. 2001 Sep 13;413(6852):179-83. doi: 10.1038/35093131.
10
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.通过转录共激活因子 PGC-1 对肝脏糖异生的调控。
Nature. 2001 Sep 13;413(6852):131-8. doi: 10.1038/35093050.
Zotero 插件