成纤维细胞生长因子-2在鸡胚绒毛尿囊膜血管形成中的作用。
The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane.
作者信息
Ribatti D, Presta M
机构信息
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
出版信息
J Cell Mol Med. 2002 Jul-Sep;6(3):439-46. doi: 10.1111/j.1582-4934.2002.tb00524.x.
Abstract
The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.
摘要
绒毛尿囊膜（CAM）是一种胚外膜，作为气体交换表面，其呼吸功能由广泛的毛细血管网络提供。CAM血管系统的发育是一个复杂的、高度调控的过程，它依赖于内皮细胞和非内皮细胞表达的遗传和表观遗传因素。尽管有证据表明几种生长因子在CAM试验中具有血管生成作用，但它们在CAM血管系统发育中的作用却鲜有研究。本文综述了我们关于外源性和内源性成纤维细胞生长因子-2（FGF-2）在CAM血管生成中作用的研究。所有这些研究的结果都支持FGF-2作为血管生成的自分泌旁分泌刺激因子的重要性及其在鸟类胚胎血管系统发育中的关键作用。
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