Gupta Yogendra K, Sinha Kusum, Chaudhary Geeta
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India.
J Neurol Sci. 2002 Nov 15;203-204:267-71. doi: 10.1016/s0022-510x(02)00303-9.
The effect on cognition was evaluated in the transient ischemia model of stroke in rats. Male Wistar rats were subjected to 2 h of transient ischemia by occluding the middle cerebral artery using the 4-0 intraluminal nylon thread. Neurological tests performed after 24 h, 7 and 15 days of middle cerebral artery (MCA) occlusion showed motor impairment as evidenced by decrease in the rota rod performance test. This was also confirmed histologically. However, when the learning and memory tests were performed, no change was observed in the learning and behavior as evidenced by insignificant difference in the retention latency in the passive avoidance test (334+/-31 s) and the transfer latency in the elevated plus maze (11+/-4.5 s) as compared to the sham-operated rats 369+/-34 and 8+/-1.7 s, respectively. The results of the present study demonstrates that transient occlusion of middle cerebral artery does not impair the learning and memory behavior of the rats.
在大鼠短暂性脑缺血模型中评估了对认知的影响。雄性Wistar大鼠通过使用4-0腔内尼龙线阻塞大脑中动脉，经历2小时的短暂性脑缺血。在大脑中动脉（MCA）阻塞24小时、7天和15天后进行的神经学测试显示出运动障碍，如转棒性能测试中的下降所证明。这也通过组织学得到证实。然而，当进行学习和记忆测试时，与假手术大鼠（分别为369±34秒和8±1.7秒）相比，被动回避测试中的保留潜伏期（334±31秒）和高架十字迷宫中的转移潜伏期（11±4.5秒）无显著差异，表明学习和行为没有变化。本研究结果表明，大脑中动脉的短暂阻塞不会损害大鼠的学习和记忆行为。
