Modo Michel
King's College London, Institute of Psychiatry, Department of Neuroscience, London, UK.
J Exp Stroke Transl Med. 2009 Jan;2(2):52-68. doi: 10.6030/1939-067X-2.2.52.
Impairments caused by stroke remain the main cause for adult disability. Despite a vigorous research effort, only 1 thrombolytic treatment has been approved in acute stroke (<3h). The limitations of preclinical studies and how these can be overcome have been the subject of various guidelines. However, often these guidelines focus on the acute stroke setting and omit long-term outcome measures, such as behaviour and neuroimaging. The considerations and practicalities of including the serial assessment of these approaches and their significance to establish therapeutic efficacy are discussed here.
中风导致的损伤仍然是成人残疾的主要原因。尽管进行了大量的研究工作，但在急性中风（<3小时）中，只有1种溶栓治疗获得了批准。临床前研究的局限性以及如何克服这些局限性一直是各种指南的主题。然而，这些指南往往侧重于急性中风情况，而忽略了长期结果指标，如行为和神经影像学。本文讨论了纳入这些方法的系列评估的考虑因素和实际情况及其对确定治疗效果的意义。
