Takeuchi Shigeto, Futamura Noritaka, Takubo Shinichirou, Noda Naomi, Minoura Hiroyuki, Toyoda Nagayasu
Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, Japan.
J Reprod Med. 2002 Oct;47(10):816-20.
To evaluate the endocrinologic profile and reproductive outcome after laparoscopic drilling using a harmonic scalpel for polycystic ovarian syndrome (PCOS) in clomiphene-resistant infertile women.
We performed a prospective, randomized study of 34 infertile women with PCOS. Group A (17 women) underwent laparoscopic ovarian drilling using a harmonic scalpel laser. Group B (control group, 17 women) underwent laparoscopic ovarian drilling using a neodymium-yttrium-aluminum-garnet laser. Change in the hormonal profile after surgery, ovulation rate and pregnancy rate were compared between groups A and B.
LH and testosterone serum levels and the LH-FSH ratio showed a statistically significant reduction after surgery, and the spontaneous ovulation rate was 94% in both groups. The cumulative pregnancy rates within two years of follow-up were 77% in group A and 60% in group B.
Laparoscopic ovarian drilling using a harmonic scalpel is an effective treatment for PCOS in clomiphene-resistant, anovulatory women: it results in ovulation and conception without major complications.
评估使用谐波手术刀进行腹腔镜打孔术治疗氯米芬抵抗的多囊卵巢综合征（PCOS）不孕女性后的内分泌情况及生殖结局。
我们对34例PCOS不孕女性进行了一项前瞻性随机研究。A组（17例女性）使用谐波手术刀激光进行腹腔镜卵巢打孔术。B组（对照组，17例女性）使用钕钇铝石榴石激光进行腹腔镜卵巢打孔术。比较A组和B组术后激素水平的变化、排卵率和妊娠率。
术后血清LH和睾酮水平以及LH - FSH比值有统计学意义的降低，两组的自发排卵率均为94%。随访两年内A组的累积妊娠率为77%，B组为60%。
使用谐波手术刀进行腹腔镜卵巢打孔术是治疗氯米芬抵抗、无排卵的PCOS女性的有效方法：它能导致排卵和受孕，且无重大并发症。
