Ogawa Shuichi, Atsuki Yusuke, Shimada Kazuhiko, Motoyama Mitsuhiro, Suzuki Tatsuya, Fujiwara Hiroyuki
Institution of Central Clinic Shimotsuke-shi Japan.
Department of Obstetrics & Gynecology Jichi Medical University Shimotsuke-shi Japan.
Reprod Med Biol. 2021 Jul 31;20(4):460-466. doi: 10.1002/rmb2.12405. eCollection 2021 Oct.
To determine the contributing factor in infertility treatment with laparoscopic ovarian drilling (LOD) to the decrease in serum anti-Müllerian hormone (AMH) levels in patients with polycystic ovarian syndrome using an ultrasonically activated device.
A retrospective analysis was performed in 60 patients (aged 23-36 years) who received 25-120 punctures in each ovary with LOD treatment from January 2014 to December 2018.
The mean decrease in serum AMH level per puncture with LOD was 0.07 ± 0.04 ng/ml in all 60 patients and 0.08 ± 0.04 ng/ml in patients with ≥10 ng/ml preoperative serum AMH level, which was significantly higher than in those with <10 ng/ml (0.05 ± 0.02 ng/ml). The mean decrease in serum AMH level per puncture in patients with body mass index (BMI) < 18.5 kg/m (0.10 ± 0.03 ng/ml) was significantly higher than in those with BMI 18.5-25 kg/m (0.07 ± 0.04 ng/ml) and >25 kg/m (0.06 ± 0.02 ng/ml).
The mean decrease in serum AMH levels per puncture with LOD using an ultrasonically activated device depends on the preoperative serum AMH level and BMI of patients.
使用超声激活设备，确定腹腔镜卵巢打孔术（LOD）治疗多囊卵巢综合征患者时导致血清抗苗勒管激素（AMH）水平降低的相关因素。
对2014年1月至2018年12月期间接受LOD治疗的60例患者（年龄23 - 36岁）进行回顾性分析，每位患者每个卵巢接受25 - 120次穿刺。
60例患者中，LOD每次穿刺后血清AMH水平的平均下降值为0.07±0.04 ng/ml；术前血清AMH水平≥10 ng/ml的患者，每次穿刺后血清AMH水平的平均下降值为0.08±0.04 ng/ml，显著高于术前血清AMH水平<10 ng/ml的患者（0.05±0.02 ng/ml）。体重指数（BMI）<18.5 kg/m²的患者每次穿刺后血清AMH水平的平均下降值（0.10±0.03 ng/ml）显著高于BMI为18.5 - 25 kg/m²的患者（0.07±0.04 ng/ml）和BMI>25 kg/m²的患者（0.06±0.02 ng/ml）。
使用超声激活设备进行LOD时，每次穿刺后血清AMH水平的平均下降值取决于患者术前血清AMH水平和BMI。
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