Erdem Ahmet, Erdem Mehmet, Biberoglu Kutay, Hayit Ozkan, Arslan Murat, Gursoy Rifat
Department of Obstetrics and Gynecology, Faculty of Medicine, Gazi University, Ankara, Turkey.
J Reprod Med. 2002 Oct;47(10):835-9.
To investigate the relation between ultrasound-based ovarian volume and antral follicle counts and hormonal parameters of ovarian reserve in a group of women with normal reproductive health.
Prospective study. One hundred eight women with at least one previous pregnancy reaching term were divided into three age groups (group 1 = 35-39 years, group 2 = 40-44 years, and group 3 = 45-50 years). Basal hormone measurements and transvaginal ultrasonography estimation of ovarian volume and follicle counts were performed in the early follicular phase (day 3) of the menstrual cycle.
There were significant differences in FSH (P < .0001) and E2 (P < .002) levels when group I was compared to groups II and III. There was a significant decrease in mean follicle counts (MFC) between groups I and III (P < .05). The decrease in mean ovarian volume (MOV) with age was not statistically significant. Age strongly correlated with MFC (r = -.38, P < .001) and weakly with MOV (r = -.29, P < .05). However, basal FSH correlated positively with age (r = .50, P < .001) and negatively with MOV (r = -.590, P < .001) and MFC (r = -.658, P < .001). Basal E2 correlated with MOV (r = .50, P < .001) and MFC (r = .50, P < .001). There was also a strong positive correlation between MFC and MOV (r = .777, P < .001).
There was a decrease in MOV and MFC with aging coincident with increasing basal FSH levels after age 35 in women with normal reproductive health.
探讨一组生殖健康正常的女性中，基于超声的卵巢体积、窦卵泡计数与卵巢储备激素参数之间的关系。
前瞻性研究。108名至少有一次足月妊娠史的女性被分为三个年龄组（第1组=35 - 39岁，第2组=40 - 44岁，第3组=45 - 50岁）。在月经周期的卵泡早期（第3天）进行基础激素测定以及经阴道超声评估卵巢体积和卵泡计数。
将第1组与第2组和第3组进行比较时，促卵泡生成素（FSH）水平（P <.0001）和雌二醇（E2）水平（P <.002）存在显著差异。第1组和第3组之间的平均卵泡计数（MFC）有显著下降（P <.05）。平均卵巢体积（MOV）随年龄的下降无统计学意义。年龄与MFC密切相关（r = -.38，P <.001），与MOV弱相关（r = -.29，P <.05）。然而，基础FSH与年龄呈正相关（r =.50，P <.001），与MOV呈负相关（r = -.590，P <.001），与MFC呈负相关（r = -.658，P <.001）。基础E2与MOV（r =.50，P <.001）和MFC（r =.50，P <.001）相关。MFC和MOV之间也存在强正相关（r =.777，P <.001）。
在生殖健康正常的女性中，35岁以后随着年龄增长，MOV和MFC下降，同时基础FSH水平升高。
