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创伤后应激障碍药物治疗的新方向

New directions in the pharmacotherapy of posttraumatic stress disorder.

作者信息

Marmar Charles R, Neylan Thomas C, Schoenfeld Frank B

机构信息

Department of Psychiatry, University of California, Department of Veterans Affairs Medical Center, San Francisco, California, USA.

出版信息

Psychiatr Q. 2002 Winter;73(4):259-70. doi: 10.1023/a:1020459916113.

DOI:10.1023/a:1020459916113
PMID:12418356
Abstract

Advances in psychopharmacology of PTSD are presented, focusing on antidepressants, adrenergic agents, antianxiety agents, and mood stabilizers. Treatment recommendations are related to recent advances in the understanding of the biology of PTSD. Pharmacotherapy of PTSD in children and adolescents is discussed, including recommended dose ranges. Recommendations are specified for pharmacotherapy of trauma survivors in the immediate aftermath of traumatic exposure, and for those with acute and chronic posttraumatic stress disorders.

摘要

介绍了创伤后应激障碍(PTSD)心理药理学的进展,重点关注抗抑郁药、肾上腺素能药物、抗焦虑药和心境稳定剂。治疗建议与PTSD生物学认识的最新进展相关。讨论了儿童和青少年PTSD的药物治疗,包括推荐剂量范围。明确了针对创伤暴露后即刻的创伤幸存者以及急性和慢性创伤后应激障碍患者的药物治疗建议。

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引用本文的文献

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Posttraumatic stress disorder in children and adolescents: a review of psychopharmacological treatment.儿童和青少年创伤后应激障碍:精神药理学治疗综述。
Child Psychiatry Hum Dev. 2010 Dec;41(6):624-40. doi: 10.1007/s10578-010-0192-3.
2
Brief report: Utility of a short screening scale for DSM-IV PTSD in primary care.简短报告:初级保健中用于筛查《精神疾病诊断与统计手册》第四版创伤后应激障碍的简短量表的效用
J Gen Intern Med. 2006 Jan;21(1):65-7. doi: 10.1111/j.1525-1497.2005.00292.x.
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SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations.

本文引用的文献

1
Posttraumatic stress disorder and quality of life: results across 64 weeks of sertraline treatment.创伤后应激障碍与生活质量:舍曲林治疗64周的结果
J Clin Psychiatry. 2002 Jan;63(1):59-65. doi: 10.4088/jcp.v63n0112.
2
Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report.开放标签托吡酯作为慢性平民创伤后应激障碍的主要或辅助治疗:初步报告。
J Clin Psychiatry. 2002 Jan;63(1):15-20. doi: 10.4088/jcp.v63n0104.
3
Pilot study of secondary prevention of posttraumatic stress disorder with propranolol.
创伤后应激障碍中选择性5-羟色胺再摄取抑制剂与非选择性5-羟色胺再摄取抑制剂的比较:最新进展及建议
Drugs. 2004;64(4):383-404. doi: 10.2165/00003495-200464040-00004.
普萘洛尔用于创伤后应激障碍二级预防的初步研究。
Biol Psychiatry. 2002 Jan 15;51(2):189-92. doi: 10.1016/s0006-3223(01)01279-3.
4
An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder.一项关于奈法唑酮治疗慢性战斗相关创伤后应激障碍的开放标签、为期12周的临床和睡眠脑电图研究。
J Clin Psychiatry. 2001 Oct;62(10):789-96. doi: 10.4088/jcp.v62n1007.
5
Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy.加巴喷丁用于创伤后应激障碍:一项辅助治疗的回顾性临床系列研究。
Ann Clin Psychiatry. 2001 Sep;13(3):141-6. doi: 10.1023/a:1012281424057.
6
Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study.帕罗西汀治疗慢性创伤后应激障碍的疗效与安全性:一项固定剂量、安慰剂对照研究。
Am J Psychiatry. 2001 Dec;158(12):1982-8. doi: 10.1176/appi.ajp.158.12.1982.
7
Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study.舍曲林预防创伤后应激障碍复发的疗效:一项28周双盲、安慰剂对照研究的结果。
Am J Psychiatry. 2001 Dec;158(12):1974-81. doi: 10.1176/appi.ajp.158.12.1974.
8
Olanzapine treatment for post-traumatic stress disorder: an open-label study.奥氮平治疗创伤后应激障碍:一项开放标签研究。
Int Clin Psychopharmacol. 2001 Nov;16(6):331-7. doi: 10.1097/00004850-200111000-00003.
9
Fluvoxamine and sleep disturbances in posttraumatic stress disorder.氟伏沙明与创伤后应激障碍中的睡眠障碍
J Trauma Stress. 2001 Jul;14(3):461-7. doi: 10.1023/A:1011100420978.
10
Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment.舍曲林治疗创伤后应激障碍:24周开放标签延续治疗的结果
J Clin Psychiatry. 2001 May;62(5):325-31. doi: 10.4088/jcp.v62n0503.