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[凝胶衍生生物活性陶瓷作为骨替代物的体内研究]

[Gel derived bioactive ceramic as bone substitute--an in vivo study].

作者信息

Niedzielski Kryspin, Wilamski Maciej, Synder Marek

机构信息

Katedra i Klinika Ortopedii, Akademia Medyczna w Łodzi.

出版信息

Chir Narzadow Ruchu Ortop Pol. 2002;67(4):385-94.

PMID:12418403
Abstract

The paper presents the histopathological and radiological study performed on a series of male, mixed-race rabbits. All rabbits had a 20 x 4 x 4 mm-bone fragment extracted from the radial bone according to a modified technique by Scmitt and Weller. In the right radius bone the bone defect was filled with approximately 0.5 cm3 bioglass S2. In the left rius, which served as control, allogenic bone graft (the size of the defect) collected from the tibia and femur was implanted. Rabbits were sacrificed 3, 6 and 12 weeks after the procedure and histopathological and radiological studies were performed. These studies revealed a heterogeneous increase of new bone regeneration in all three phases of the study. The S2 biomaterial both stimulated and accelerated bone regeneration in the rabbits.

摘要

本文介绍了对一系列雄性混血兔进行的组织病理学和放射学研究。所有兔子均按照施密特和韦勒改良技术从桡骨取出一块20×4×4毫米的骨碎片。在右侧桡骨中,骨缺损处填充了约0.5立方厘米的生物玻璃S2。在作为对照的左侧桡骨中,植入了从胫骨和股骨采集的同种异体骨移植物(缺损大小)。术后3周、6周和12周处死兔子,并进行组织病理学和放射学研究。这些研究表明,在研究的所有三个阶段,新骨再生均有不同程度的增加。S2生物材料既刺激又加速了兔子的骨再生。

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