Chan C, Thompson I, Robinson P, Wilson J, Hench L
Department of Oral & Maxillofacial Surgery, Guy's Hospital, London, UK.
Int J Oral Maxillofac Surg. 2002 Feb;31(1):73-7. doi: 10.1054/ijom.2001.0143.
Allogenic and alloplastic bone graft substitutes serve either as bioinert or bioactive osteoconductors. Bioglass is a bioactive osteoconductor and also shows osteoproductive effects due to its high level of bioactivity. However, the material lacks some cohesiveness when used in augmenting certain bony surfaces, i.e. large or pleomorphic defects. The addition of medium molecular weight dextran modifies the particulate to a putty consistency and improves the handling characteristics. The objective of this study is to evaluate the influence of dextran upon the bioactive properties of Bioglass. Standardized bony defects in the lateral femoral condyles in adult New Zealand white rabbits were filled with one of five material groups: (1) autogenous bone; (2) Bioglass particulate; (3) Bioglass particulate mixed with dextran to a putty-like consistency; (4) a mixture of Bioglass and autogenous bone; (5) a mixture of Bioglass putty with autogenous bone. Postoperative healing was observed after periods of 2 days, 1, 2, 3, 6 and 12 weeks. Results showed no evidence of toxicity in the dextran-containing materials, and defects in all test groups showed 100% bony ingrowth within 6 weeks. The addition of medium molecular weight dextran did not appear to alter the bioactive properties of Bioglass and had no adverse influence upon the ingrowth of bone into the defect sites.
同种异体和异质骨移植替代物可作为生物惰性或生物活性骨传导材料。生物玻璃是一种生物活性骨传导材料，由于其高生物活性还具有成骨作用。然而，当用于填充某些骨表面时，即大的或多形性缺损时，该材料缺乏一定的粘性。添加中分子量葡聚糖可将颗粒改变为油灰状稠度并改善其操作特性。本研究的目的是评估葡聚糖对生物玻璃生物活性特性的影响。成年新西兰白兔股骨外侧髁的标准化骨缺损用以下五组材料之一填充：(1)自体骨；(2)生物玻璃颗粒；(3)与葡聚糖混合至油灰状稠度的生物玻璃颗粒；(4)生物玻璃与自体骨的混合物；(5)生物玻璃油灰与自体骨的混合物。在术后2天、1、2、3、6和12周观察愈合情况。结果显示含葡聚糖的材料无毒性证据，所有测试组的缺损在6周内均有100%的骨长入。中分子量葡聚糖的添加似乎并未改变生物玻璃的生物活性特性，且对骨长入缺损部位没有不利影响。
