MMWR Morb Mortal Wkly Rep. 2002 Oct 11;51(40):902.
Staphylococcus aureus is one of the most common causes of hospital- and community-acquired infections. Since the recognition of vancomycin-resistant enterococci in 1988, the emergence of vancomycin-resistant S. aureus (VRSA) (minimum inhibitory concentration [MIC] > or = 32 microg/mL) has been anticipated. The transfer of the genetic element containing the vanA vancomycin resistance gene from Enterococcus faecalis to S. aureus was demonstrated in the laboratory in 1992; the first clinical infection with VRSA was reported in July 2002. This report describes the second documented clinical isolate of VRSA from a patient.
金黄色葡萄球菌是医院获得性感染和社区获得性感染最常见的病因之一。自1988年发现耐万古霉素肠球菌以来，人们一直预期会出现耐万古霉素金黄色葡萄球菌（VRSA，最低抑菌浓度[MIC]≥32μg/mL）。1992年在实验室证实了含vanA万古霉素耐药基因的遗传元件从粪肠球菌转移至金黄色葡萄球菌；2002年7月报道了首例VRSA临床感染病例。本报告描述了从一名患者身上分离出的第二株有记录的VRSA临床菌株。
