Ahuja M C, Khamar Bakulesh
J Indian Med Assoc. 2002 May;100(5):334-5.
Antibiotic associated diarrhoea is known to occur with broad spectrum antibiotics. Lactobacillus has been used for prophylaxis and therapy of this condition. In a double blind controlled study, the antibiotic containing ampicillin (250 mg) and cloxacillin (250 mg) with or without protected lactobacilli was evaluated in 740 patients undergoing cataract surgery. The incidence of diarrhoea in patients receiving plain antibiotic was 13.3% compared to 0.0% in patients receiving antibiotic with protected lactobacilli (p<0.001). The study demonstrates that antibiotic formulations containing protected lactobacilli maintain prophylactic effect of lactobacilli.
已知使用广谱抗生素会引发抗生素相关性腹泻。乳酸杆菌已被用于这种疾病的预防和治疗。在一项双盲对照研究中，对740名接受白内障手术的患者评估了含氨苄西林（250毫克）和氯唑西林（250毫克）的抗生素，以及添加或未添加受保护乳酸杆菌的情况。接受普通抗生素治疗的患者腹泻发生率为13.3%，而接受含受保护乳酸杆菌抗生素治疗的患者腹泻发生率为0.0%（p<0.001）。该研究表明，含有受保护乳酸杆菌的抗生素制剂能维持乳酸杆菌的预防作用。
