Jirapinyo Pipop, Densupsoontorn Narumon, Thamonsiri Nuchnoi, Wongarn Renu
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2002 Aug;85 Suppl 2:S739-42.
Probiotics administration has been claimed to prevent antibiotic-associated diarrhea. The investigators thus conducted a double blind, placebo controlled study of providing probiotics to infants and children with severe bacterial infections and receiving broad spechum antibiotics. The results of the study showed that the group receiving probiotics had fewer diarrheal episodes (37.5%) than the control group (80%), although the numbers were too small for statistical analysis. In conclusion, probiotics administration to patients receiving high doses of broad spectrum antibiotics may prevent the occurrence of antibiotic-associated diarrhea. A further study with a larger number is required.
有人声称服用益生菌可预防抗生素相关性腹泻。因此，研究人员进行了一项双盲、安慰剂对照研究，为患有严重细菌感染并接受广谱抗生素治疗的婴幼儿提供益生菌。研究结果显示，服用益生菌的组腹泻发作次数（37.5%）低于对照组（80%），不过由于样本数量过少无法进行统计分析。总之，给接受大剂量广谱抗生素治疗的患者服用益生菌可能会预防抗生素相关性腹泻的发生。需要开展更大规模的进一步研究。
