Lamont Leigh A, Bulmer Barret J, Sisson David D, Grimm Kurt A, Tranquilli William J
J Am Vet Med Assoc. 2002 Nov 1;221(9):1276-81. doi: 10.2460/javma.2002.221.1276.
To evaluate the effects of medetomidine on dynamic left ventricular outflow tract (LVOT) obstruction in cats with left ventricular hypertrophy.
Clinical trial.
6 domestic shorthair cats with echocardiographic evidence of dynamic LVOT obstruction.
Cats were restrained in lateral recumbency, and baseline M-mode and Doppler echocardiographic examinations were performed. An ECG was recorded continuously, and blood pressure was measured indirectly with Doppler instrumentation. Medetomidine (20 microg/kg 19.1 microg/lb]) was then administered i.m., and examinations were repeated 15 minutes later.
Significant decreases in heart rate, LVOT velocity, and the LVOT pressure gradient were documented following medetomidine administration. After adjusting for the effects of heart rate by ANCOVA, there were no significant differences in any other systolic or diastolic indices of left ventricular function.
Results suggest that administration of medetomidine to cats with dynamic LVOT obstruction may result in elimination of outflow tract obstruction; medetomidine may be a suitable sedative and analgesic agent in this subpopulation of cats.
评估美托咪定对左心室肥厚猫动态左心室流出道（LVOT）梗阻的影响。
临床试验。
6只经超声心动图证实存在动态LVOT梗阻的家养短毛猫。
将猫侧卧固定，进行基线M型和多普勒超声心动图检查。连续记录心电图，并用多普勒仪器间接测量血压。然后肌肉注射美托咪定（20微克/千克[19.1微克/磅]），15分钟后重复检查。
美托咪定给药后，心率、LVOT速度和LVOT压力梯度显著降低。通过协方差分析校正心率影响后，左心室功能的任何其他收缩期或舒张期指标均无显著差异。
结果表明，对存在动态LVOT梗阻的猫给予美托咪定可能会消除流出道梗阻；美托咪定可能是这类猫合适的镇静和镇痛剂。
