Sadjadi Reza, Nasrollahzadeh Masouleh Mohammad, Asghari Ahmad, Bokaie Saied
Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University,Tehran, Iran.
Department of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Vet Res Forum. 2021;12(3):383-386. doi: 10.30466/vrf.2020.113899.2710. Epub 2021 Sep 15.
The purpose of the present study was to evaluate effects of medetomidine on left ventricular outflow tract (LVOT) velocity in domestic short-haired cats. Eighteen healthy adult male domestic short-haired cats were used for this study. All animals were client-owned. Echocardiography machine with 7.50 MHz transducer was used. Specific veterinary two-dimensional and pulse-waved echocardiogram images in apical five chamber right parasternal view were obtained and blood velocity in LVOT was calculated. After baseline echocardiographic recordings, 0.04 mg kg of medetomidine was intramuscularly administered to each animal and LVOT velocity was calculated after 15 (T15), 50 (T30) and 80 (T80) min following drug administration. The LVOT velocity values (mean SEM) of cats in baseline were 1.06 0.04 m sec. There were significant differences between baseline and T15 and T30 regarding mean LVOT values. Age and weight had no significant effect on LVOT velocity values. The LVOT velocity values of T15, T50 and T80 were 0.77 0.04, 0.80 0.02 and 0.960.03 m sec, respectively. Our findings revealed significant decrease in mean LVOT velocity up to 50 min following medetomidine administration. The present study determined normal LVOT velocity range for a small population of cats before and after intra-muscular medetomidine administration.
本研究的目的是评估美托咪定对家养短毛猫左心室流出道（LVOT）速度的影响。本研究使用了18只健康的成年雄性家养短毛猫。所有动物均为客户所有。使用配有7.50 MHz换能器的超声心动图仪。获取心尖五腔右胸骨旁视图中的特定兽医二维和脉冲波超声心动图图像，并计算LVOT中的血流速度。在进行基线超声心动图记录后，给每只动物肌肉注射0.04 mg/kg的美托咪定，并在给药后15分钟（T15）、50分钟（T30）和80分钟（T80）计算LVOT速度。猫在基线时的LVOT速度值（平均值±标准误）为1.06±0.04 m/sec。基线与T15和T30之间的平均LVOT值存在显著差异。年龄和体重对LVOT速度值无显著影响。T15、T50和T80时的LVOT速度值分别为0.77±0.04、0.80±0.02和0.96±0.03 m/sec。我们的研究结果显示，美托咪定给药后长达50分钟，平均LVOT速度显著降低。本研究确定了一小部分猫在肌肉注射美托咪定前后的正常LVOT速度范围。
