通往核因子-κB的两条途径。
Two pathways to NF-kappaB.
作者信息
Pomerantz Joel L, Baltimore David
机构信息
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Mol Cell. 2002 Oct;10(4):693-5. doi: 10.1016/s1097-2765(02)00697-4.
Abstract
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune disease.
摘要
核因子-κB是一种对固有免疫和适应性免疫至关重要的转录因子。最近，一种非经典的核因子-κB激活途径出现了。最近的四篇论文阐述了该途径的生理作用，并拓展了我们对淋巴细胞发育和器官发生的理解，在自身免疫性疾病治疗方面具有潜在应用价值。
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