免疫与炎症中的非经典NF-κB信号通路
The non-canonical NF-κB pathway in immunity and inflammation.
作者信息
Sun Shao-Cong
机构信息
Department of Immunology, The University of Texas MD Anderson Cancer Center, MD Anderson Cancer Center UT Heath Graduate School of Biomedical Sciences, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA.
出版信息
Nat Rev Immunol. 2017 Sep;17(9):545-558. doi: 10.1038/nri.2017.52. Epub 2017 Jun 5.
Abstract
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and non-canonical signalling pathways, which differ in both signalling components and biological functions. Recent studies have revealed important roles for the non-canonical NF-κB pathway in regulating different aspects of immune functions. Defects in non-canonical NF-κB signalling are associated with severe immune deficiencies, whereas dysregulated activation of this pathway contributes to the pathogenesis of various autoimmune and inflammatory diseases. Here we review the signalling mechanisms and the biological function of the non-canonical NF-κB pathway. We also discuss recent progress in elucidating the molecular mechanisms regulating non-canonical NF-κB pathway activation, which may provide new opportunities for therapeutic strategies.
摘要
转录因子核因子-κB（NF-κB）家族可通过经典和非经典信号通路激活，这两种信号通路在信号传导成分和生物学功能上均有所不同。最近的研究揭示了非经典NF-κB通路在调节免疫功能的不同方面发挥的重要作用。非经典NF-κB信号传导缺陷与严重的免疫缺陷有关，而该通路的失调激活则促成了各种自身免疫性疾病和炎症性疾病的发病机制。在此，我们综述非经典NF-κB通路的信号传导机制和生物学功能。我们还讨论了在阐明调节非经典NF-κB通路激活的分子机制方面的最新进展，这可能为治疗策略提供新的机遇。
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