Fedor Martha J, Westhof Eric
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, MB 35, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Mol Cell. 2002 Oct;10(4):703-4. doi: 10.1016/s1097-2765(02)00700-1.
Twenty years have passed since the first reports that certain RNAs mediate self-splicing and precursor tRNA processing reactions in the absence of proteins. An entire field emerged to learn how RNAs that lack the chemical versatility of amino acids nonetheless assemble into enzymes that accelerate chemical reactions with efficiencies that rival those of their protein counterparts.
自从首次报道某些RNA在没有蛋白质的情况下介导自我剪接和前体tRNA加工反应以来，已经过去了二十年。一个完整的领域应运而生，旨在研究缺乏氨基酸化学多样性的RNA如何组装成酶，以与蛋白质对应物相媲美的效率加速化学反应。
