Ahmad Kami, Henikoff Steven
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Cell. 2002 Nov 1;111(3):281-4. doi: 10.1016/s0092-8674(02)01081-4.
Current models for epigenetic gene silencing envision a static relationship between histone modifications and transcription. However, evidence for nucleosome mobility and replacement favors a dynamic model that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.
当前的表观遗传基因沉默模型设想组蛋白修饰与转录之间存在静态关系。然而，核小体移动性和替换的证据支持一种动态模型，该模型可能解释从斑驳现象到雷特综合征的神经限制等各种现象。
