Chemical modification of reveromycin A and its biological activities.
作者信息
Shimizu Takeshi, Usui Takeo, Machida Kiyotaka, Furuya Kouichi, Osada Hiroyuki, Nakata Tadashi
机构信息
Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan.
出版信息
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6. doi: 10.1016/s0960-894x(02)00782-5.
Abstract
Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.
摘要
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