Shimizu Takeshi, Usui Takeo, Machida Kiyotaka, Furuya Kouichi, Osada Hiroyuki, Nakata Tadashi
Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan.
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6. doi: 10.1016/s0960-894x(02)00782-5.
Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.
