Natural Product Biosynthesis Research Unit, RIKEN Centre for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
J Antibiot (Tokyo). 2022 Aug;75(8):432-444. doi: 10.1038/s41429-022-00539-1. Epub 2022 Jul 1.
Streptomyces represents an important reservoir for biologically active natural products. Understanding the biosynthetic mechanism and the mode of gene expression is important for enhanced metabolite production and evaluation of biological activities. This review provides an overview of biosynthetic studies investigating reveromycin and β-carboline biomediators that enhanced the production of reveromycin in Streptomyces sp. SN-593 through activation of the LuxR family regulator. Furthermore, based on the optimal expression of a pathway specific regulator controlling the mevalonate pathway gene cluster, Streptomyces sp. SN-593 was developed as a platform for terpenoid compounds mass production.
链霉菌代表了生物活性天然产物的重要资源库。了解生物合成机制和基因表达模式对于增强代谢产物的生产和生物活性的评估非常重要。本综述概述了生物合成研究，研究了 reveromycin 和 β-咔啉生物介体，通过激活 LuxR 家族调节剂来增强 Streptomyces sp. SN-593 中 reveromycin 的产生。此外，基于控制甲羟戊酸途径基因簇的途径特异性调节剂的最佳表达，开发了 Streptomyces sp. SN-593 作为萜类化合物大规模生产的平台。
