Trifluoromethyl ketones as inhibitors of histone deacetylase.
作者信息
Frey Robin R, Wada Carol K, Garland Robert B, Curtin Michael L, Michaelides Michael R, Li Junling, Pease Lori J, Glaser Keith B, Marcotte Patrick A, Bouska Jennifer J, Murphy Shannon S, Davidsen Steven K
机构信息
Cancer Research, Abbott Laboratories, Abbott Park, IL 60064, USA.
出版信息
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. doi: 10.1016/s0960-894x(02)00754-0.
Abstract
Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar inhibitors such as 20 that demonstrated antiproliferative effects against the HT1080 and MDA 435 cell lines.
摘要
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