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加德纳综合征——病例报告。

Gardner's syndrome - a case report.

作者信息

Payne M, Anderson J A, Cook J

机构信息

Dental Radiology and Assessment and Casualty, Charles Clifford Dental Hospital, Wellesley Road, Sheffield S10 2SZ.

出版信息

Br Dent J. 2002 Oct 12;193(7):383-4. doi: 10.1038/sj.bdj.4801571.

Abstract

Gardner's syndrome is the association of multiple colonic polyps (familial adenomatous polyposis coli - FAP) with sebaceous cysts and jaw osteomas. The significance of this dominantly inherited condition to the dentist is that the colonic polyps usually undergo malignant change by the fourth decade and the extra-intestinal lesions may be apparent before those in the bowel. As such, early detection of multiple jaw osteomas and/or multiple sebaceous cysts (particularly on the scalp) may lead to appropriate further investigation and treatment which might be life saving. Diagnosis of this condition also has implications for other family members.

摘要

加德纳综合征是指多发性结肠息肉(家族性腺瘤性息肉病 - FAP)与皮脂腺囊肿及颌骨骨瘤并存。这种常染色体显性遗传病对牙医的意义在于,结肠息肉通常在40岁前发生恶变,而肠道外病变可能在肠道病变出现之前就已显现。因此,早期发现多发性颌骨骨瘤和/或多发性皮脂腺囊肿(尤其是头皮上的)可能会促使进行适当的进一步检查和治疗,这可能会挽救生命。对这种疾病的诊断对其他家庭成员也有影响。

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