Wijn M A, Keller J J, Giardiello F M, Brand H S
Departments of Oral-Maxillofacial Surgery and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Oral Dis. 2007 Jul;13(4):360-5. doi: 10.1111/j.1601-0825.2006.01293.x.
Patients with familial adenomatous polyposis (FAP) develop multiple premalignant colorectal adenomas. Untreated, one or more of these polyps will progress to colorectal carcinoma in middle-aged adults. Extra-intestinal manifestations of FAP are frequently observed and this combination has been called Gardner's syndrome. Oral and maxillofacial symptoms of FAP include an increased risk of jaw osteomas, odontomas and supernumerary or unerupted teeth. Early diagnosis of FAP is crucial and may be life saving. As oral signs usually precede gastrointestinal symptoms, the dentist may play an important role in the diagnosis of FAP.
患有家族性腺瘤性息肉病（FAP）的患者会出现多个癌前结直肠腺瘤。如果不进行治疗，这些息肉中的一个或多个将在中年成年人中发展为结直肠癌。FAP的肠外表现经常可见，这种组合被称为加德纳综合征。FAP的口腔颌面症状包括颌骨骨瘤、牙瘤以及多生牙或阻生牙的风险增加。FAP的早期诊断至关重要，可能会挽救生命。由于口腔症状通常先于胃肠道症状出现，牙医在FAP的诊断中可能发挥重要作用。
