Serrano-Munuera C, Rojas-García R, Gallardo E, De Luna N, Buenaventura I, Ferrero M, García T, García-Merino J A, González-Rodríguez C, Guerriero A, Marco M, Márquez C, Grau J M, Graus F, Illa I
Dept. of Neurology, Institut de Recerca, Hospital de la Sta. Creu i St. Pau, Universitat Autònoma de Barcelona, St. Antoni Ma Claret 167, Barcelona 08025, Spain.
J Neurol. 2002 Nov;249(11):1525-8. doi: 10.1007/s00415-002-0882-2.
Antidisialosyl antibodies were found in two out of 13 patients with chronic idiopathic ataxic neuropathy (CIAN) and not in 32 patients with different sensory neuropathies of known cause. This finding confirms the association of antidisialosyl antibodies and CIAN regardless of the absence of the M band. These antibodies may have pathogenic relevance; however, larger series are needed to establish their clinical significance.
在13例慢性特发性共济失调性神经病(CIAN)患者中,有2例发现了抗唾液酸抗体,而在32例已知病因的不同感觉神经病患者中未发现。这一发现证实了抗唾液酸抗体与CIAN之间的关联,无论是否存在M带。这些抗体可能具有致病相关性;然而,需要更大规模的系列研究来确定它们的临床意义。