Vernino Steven, Wolfe Gil I
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9036, USA.
Neurol Clin. 2007 Feb;25(1):29-46. doi: 10.1016/j.ncl.2006.10.002.
Many autoantibodies have been described in association with peripheral neuropathy, but the use of antibody testing in clinical practice remains a matter of some debate. Serum autoantibodies to gangliosides or glycoproteins are implicated in a variety of sensory and motor neuropathy syndromes. Paraneoplastic antibodies help identify patients who have a neuropathy related to an underlying malignancy. Detection of an autoantibody in the right clinical setting provides some evidence that the peripheral nerve disturbance is immune mediated and that immunomodulatory therapy may be of benefit.
许多自身抗体已被描述与周围神经病变相关，但在临床实践中使用抗体检测仍存在一些争议。针对神经节苷脂或糖蛋白的血清自身抗体与多种感觉和运动神经病变综合征有关。副肿瘤性抗体有助于识别患有与潜在恶性肿瘤相关神经病变的患者。在恰当的临床环境中检测到自身抗体，可为周围神经功能障碍是免疫介导的且免疫调节治疗可能有益提供一些证据。
