Poma Roberto, Parent Joane M, Holmberg David L, Partlow Gary D, Monteith Gabrielle, Sylvestre Anne M
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
J Am Vet Med Assoc. 2002 Jul 1;221(1):60-4. doi: 10.2460/javma.2002.221.60.
To evaluate use of transcranial magnetic motor evoked potentials for assessment of the functional integrity of the cervical spinal cord in large-breed dogs with cervical spinal cord disease.
Randomized, controlled, masked study.
10 healthy large-breed control dogs and 25 large-breed dogs with cervical spinal cord diseases.
Affected dogs were allocated to 3 groups on the basis of neurologic status: signs of neck pain alone, ambulatory with ataxia in all limbs, or nonambulatory. Transcranial magnetic stimulation was performed on each dog with the same standard technique. Motor evoked potentials (MEP) were recorded from electrodes inserted in the tibialis cranialis muscle. Following the procedure, each dog was anesthetized and cervical radiography, CSF analysis, and cervical myelography were performed. The MEP latencies and amplitudes were correlated with neurologic status of the dogs after correction for neuronal path length.
Mean MEP latencies and amplitudes were significantly different between control dogs and dogs in each of the 3 neurologic categories, but were not significantly different among dogs in the 3 neurologic categories. A linear association was evident between MEP latencies and amplitudes and severity of neurologic deficits; the more severe the neurologic deficits, the more prolonged the latencies and the more decreased the amplitudes.
Transcranial magnetic MEP are useful to assess severity of cervical spinal cord disease in large-breed dogs. Impairment of the functional integrity of the cervical spinal cord was found even in dogs with neck pain alone.
评估经颅磁运动诱发电位在评估患有颈脊髓疾病的大型犬颈脊髓功能完整性方面的应用。
随机、对照、盲法研究。
10只健康的大型对照犬和25只患有颈脊髓疾病的大型犬。
根据神经学状态将患病犬分为3组：仅颈部疼痛体征、四肢共济失调可行走或不能行走。采用相同的标准技术对每只犬进行经颅磁刺激。从插入胫骨前肌的电极记录运动诱发电位（MEP）。操作完成后，对每只犬进行麻醉，并进行颈椎X线摄影、脑脊液分析和颈椎脊髓造影。在校正神经元路径长度后，将MEP潜伏期和波幅与犬的神经学状态进行关联。
对照犬与3个神经学类别中的每一类犬的平均MEP潜伏期和波幅均有显著差异，但3个神经学类别中的犬之间无显著差异。MEP潜伏期和波幅与神经功能缺损的严重程度之间存在明显的线性关联；神经功能缺损越严重，潜伏期越长，波幅降低越明显。
经颅磁MEP有助于评估大型犬颈脊髓疾病的严重程度。即使是仅患有颈部疼痛的犬，也发现其颈脊髓功能完整性受损。
