Maccioni E, Cardia M C, Bonsignore L, Plumitallo A, Pellerano M L, De Logu A
Dipartimento Farmaco Chimico Tecnologico, Cagliari, Italy.
Farmaco. 2002 Oct;57(10):809-17. doi: 10.1016/s0014-827x(02)01288-0.
It is known that some derivatives of both thiourea and thiosemicarbazide exhibit potent anti-microbial activity. In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure-activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring.
已知硫脲和氨基硫脲的一些衍生物具有强大的抗微生物活性。为了研究此类结构的结构修饰对生物学性质的影响，我们合成并研究了一些亚芳基异硫代氨基脲。在本文中，我们报告了一些异硫代氨基脲的合成及其构效关系，其中亚芳基已被环烷基取代，硫原子已被不同取代或包含在噻唑环中。
