Lloyd Mary E, Lederman Sally A
Istituto Maestre Pie Filippini, Rome, Italy.
Indian J Pediatr. 2002 Sep;69(9):771-4. doi: 10.1007/BF02723689.
For years it has been shown that more children die from moderate malnutrition (MM) than severe. Till yet few studies deal specifically with identifying these children. This study attempts to statistically determine the appropriate anthropometric measures and cut-off points for diagnosing moderate malnutrition in preschool children.
Anthropometric measurements were obtained from 609 preschool children from the cities of Adigrat, Ethiopia; Janampet, India; San Paulo, Brazil. The values were used to determine the sensitivity, specificity, positive predictive value (PPV) and likelihood ratio (LR) of each index studied. The optimum cutoff point for each index was considered to be the cutoff point with the maximum Kappa coefficient for efficiency. The McNemar Test for the significance of changes was used to determine if these findings were in agreement when applied to this data.
Weight for height (WFH) at each site had the highest PPV and LR of 4 but was not signficant by the McNemar Test. Mid-upper arm circumference (MUAC) in India had the same PPV (77%) as WFH but a LR of 2. MUAC in India, Brazil and Ethiopia tested significantly for the McNemar Test. The cut-off point for MUAC in India and Brazil was determined to be <15.5 cm in India and Brazil but was <15 cm in Ethiopia. Waist circumference in India tested a significantly PPV of 64%, and a LR of 2.
These results show that WFH and MUAC could be used with WFA to identify the MM child. The cut-off points for MUAC may vary per location. WC positive data suggests further study is warranted. The McNemar findings yielded significant evidence that statistically determined indicators can be established to identify MM. With further study these methods may prove to be an important component in the efforts to improve child survival.
多年来的研究表明,死于中度营养不良(MM)的儿童比死于重度营养不良的儿童更多。然而,迄今为止很少有研究专门针对识别这些儿童。本研究试图通过统计学方法确定诊断学龄前儿童中度营养不良的合适人体测量指标和切点。
对来自埃塞俄比亚阿迪格拉特市、印度贾南佩特市、巴西圣保罗市的609名学龄前儿童进行人体测量。这些数值用于确定所研究的每个指标的敏感性、特异性、阳性预测值(PPV)和似然比(LR)。每个指标的最佳切点被认为是效率最高的Kappa系数对应的切点。使用McNemar检验来确定这些发现应用于该数据时是否一致。
每个地点的身高别体重(WFH)的PPV和LR最高,均为4,但经McNemar检验无统计学意义。印度的上臂中部周长(MUAC)的PPV与WFH相同(77%),但LR为2。印度、巴西和埃塞俄比亚的MUAC经McNemar检验有统计学意义。印度和巴西MUAC的切点确定为<15.5厘米,而埃塞俄比亚为<15厘米。印度的腰围PPV为64%,有统计学意义,LR为2。
这些结果表明,WFH和MUAC可与年龄别体重(WFA)一起用于识别中度营养不良儿童。MUAC的切点可能因地点而异。腰围的阳性数据表明有必要进一步研究。McNemar检验结果提供了重要证据,表明可以通过统计学方法确定识别中度营养不良的指标。通过进一步研究,这些方法可能会成为改善儿童生存努力中的重要组成部分。