Raiti S, Blizzard R M, Penny R, Migeon C J
Acta Endocrinol (Copenh). 1975 Oct;80(2):275-83. doi: 10.1530/acta.0.0800275.
The urinary excretion method and the constant infusion technique were used to estimate hFSH production rates (PR) in three normal men (aged 25-40 years). Both studies were also done in a hypophysectomized nine year old boy. The PR of hFSH in the urinary excretion studies ranged from 20.0 to 45.7 IU/24 h, whereas the constant infusion studies yielded PR'S OF 68.7 to 107.8 IU/24 h. Possible reasons for the discrepancy of the results obtained by the two methods are discussed. In the hypophysectomized patient, the metabolic clearance rate (MCR) of infused hFSH was much lower (4.3 ml/min) than in the normal adults (7.8 to 12.0 ml/min) and was not affected by the dose of hFSH given.
采用尿排泄法和持续输注技术，对3名正常男性（年龄在25 - 40岁之间）的人促卵泡生成素（hFSH）分泌率（PR）进行了评估。这两项研究也在一名9岁的垂体切除术后男孩身上进行。尿排泄研究中hFSH的PR范围为20.0至45.7 IU/24小时，而持续输注研究得出的PR为68.7至107.8 IU/24小时。讨论了两种方法所得结果存在差异的可能原因。在垂体切除术后的患者中，输注的hFSH的代谢清除率（MCR）（4.3毫升/分钟）远低于正常成年人（7.8至12.0毫升/分钟），且不受所给予的hFSH剂量的影响。
