Nissen O I
Acta Ophthalmol (Copenh). 1975 Sep;53(4):537-52. doi: 10.1111/j.1755-3768.1975.tb01773.x.
The decays in the applanation pressures of both eyes, after a reduction of the aqueous secretion by means of intravenous acetazolamide, are studied with respect to shape and steepness by comparison with reference curves calculated from different values of the facility of aqueous outflow. The pressure decays in three out of four eyes with narrow-angle glaucoma exhibited "breaks" possibly resulting from a stepwise reopening of the chamber angle during the decompression. Twenty patients with intraocular hypertension and open angles could be divided into two groups according to the facility of aqueous outflow (in mul mmHg-1 min-1), estimated from approximately matching reference curves: Nine patients with facilities above 0.15 had normal visual fields and nearly indentical pressure curves of the two eyes. Out of 11 patients with facilities below 0.15, seven patients had glaucomatous visual field defects and excavated optic discs. The pressure curves of eye pairs in this low facility group showed asymmetry, and breaks were seen in approximately half of the curves. These might be caused by changes in the outflow facility due to a decompression of collapsed outflow channels. However, the morphological basis for such an interpretation is not as well founded as in the case of narrow-angle glaucoma.
通过静脉注射乙酰唑胺减少房水分泌后，研究双眼压平眼压的下降情况，通过与根据不同房水流出易度值计算出的参考曲线进行比较，来分析其形状和陡峭程度。在四例窄角型青光眼患者中，有三例眼压下降呈现出“中断”，这可能是由于减压过程中房角逐步重新开放所致。根据大致匹配的参考曲线估算房水流出易度（单位：ml mmHg⁻¹ min⁻¹），20例高眼压症且房角开放的患者可分为两组：9例房水流出易度高于0.15的患者视野正常，双眼眼压曲线几乎相同。在11例房水流出易度低于0.15的患者中，7例有青光眼性视野缺损和视盘凹陷。该低房水流出易度组中双眼的眼压曲线显示不对称，约半数曲线出现中断。这可能是由于塌陷的流出通道减压导致流出易度发生变化所致。然而，这种解释的形态学基础不如窄角型青光眼那样有充分依据。
