Zebrowska-Lupina I, Malec D, Kleinrok Z
Acta Physiol Pol. 1975 May-Jun;26(3):261-74.
Noradrenaline and dopamine injected into the lateral brain ventricle exerted a significant effect on the behavior of rats. Both amines caused a slight rise in the basic locomotor activity which was significantly increased in the animals with inhibited monoamine oxidase activity. Besides that, they suppressed the behavior of rats in the open-field test, inhibited the conditioned avoidance response, decreased body temperature and increased amphetamine-induced motor hyperactivity. Noradrenaline, in contrast to dopamine, changed the intensity of amphetamine-induced stereotypy and prolonged the action of hypnotics. The central action of both catecholamines (in higher doses especially) seemed to have a biphasic course: in the first phase after administration depression was observed which was more pronounced after noradrenaline administration, in the second phase a stimulating effect b
将去甲肾上腺素和多巴胺注入大鼠侧脑室对其行为产生了显著影响。两种胺类物质均使基础运动活动略有增加，在单胺氧化酶活性受到抑制的动物中，这种增加更为显著。除此之外，它们在旷场试验中抑制大鼠行为，抑制条件性回避反应，降低体温，并增强苯丙胺诱导的运动亢进。与多巴胺不同，去甲肾上腺素改变了苯丙胺诱导的刻板行为的强度，并延长了催眠药的作用时间。两种儿茶酚胺的中枢作用（尤其是高剂量时）似乎呈现双相过程：给药后的第一阶段观察到抑制作用，去甲肾上腺素给药后更为明显，第二阶段则出现刺激作用。
