Jagiełło-Wójtowicz E
Pol J Pharmacol Pharm. 1981 Jan-Feb;33(1):59-71.
Phenylethylamine (PEA), 10, 50 and 100 microgram/rat ivc depressed the spontaneous and explorative motor activities, did not affect the body temperature and potentiated the action of hypnotics. The PEA-induced depression of motor activity was antagonized by spiperone, phenoxybenzamine, propranolol and, slightly, by alpha-MT. In rats with total chemical destruction of catecholamine neurons and in rats with selective lesion of dopamine neurons, PEA increased motor activity. Similar effect was observed after administration of reserpine, reserpine together with 6-hydroxydopamine and yohimbine. PEA potentiated the amphetamine and apomorphine stereotypy but inhibited amphetamine hypermotility: in the latter experiment slight periodical stereotyped head movements were observed. PEA did not affect haloperidol and fluphenazine induced catalepsy. It did not change the immobility period in the behavioral despair test. In doses of 0 . 1, 1 and 10 mg/kg iv it potentiated flexor reflex of the hind paw of the spinal rat. Phentolamine (10 mg/kg iv) and propranolol (5 mg/kg iv) slightly potentiated the stimulatory effect of PEA. In doses of 50 and 100 microgram ivc PEA did not affect the level and utilization of noradrenaline, and did not change the level of dopamine but depressed its utilization in the cerebral cortex, striatum and hippocampus.
苯乙胺（PEA），剂量为10、50和100微克/大鼠静脉注射，可抑制自发和探索性运动活动，不影响体温，并增强催眠药的作用。PEA引起的运动活动抑制被舒必利、酚苄明、普萘洛尔拮抗，α-甲基酪氨酸也有轻微拮抗作用。在儿茶酚胺神经元完全化学损毁的大鼠和多巴胺神经元选择性损伤的大鼠中，PEA增加运动活动。给予利血平、利血平与6-羟基多巴胺合用以及育亨宾后也观察到类似效果。PEA增强苯丙胺和阿扑吗啡的刻板行为，但抑制苯丙胺的多动：在后一实验中观察到轻微的周期性刻板头部运动。PEA不影响氟哌啶醇和氟奋乃静诱导的僵住症。在行为绝望试验中，它不改变不动期。静脉注射剂量为0.1、1和10毫克/千克时，它增强脊髓大鼠后爪的屈肌反射。酚妥拉明（静脉注射10毫克/千克）和普萘洛尔（静脉注射5毫克/千克）轻微增强PEA的刺激作用。静脉注射剂量为50和100微克时，PEA不影响去甲肾上腺素的水平和利用，不改变多巴胺水平，但抑制其在大脑皮层、纹状体和海马中的利用。
