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去甲基敌百虫对小鼠显性致死试验的致突变性(作者译)

[The mutagenicity of desmethyltrichlorphone in dominant lethal test on mice (author's transl)].

作者信息

Dedek W, Scheufler H, Fischer G W

出版信息

Arch Toxicol. 1975 Feb 14;33(2):163-8. doi: 10.1007/BF00353241.

DOI:10.1007/BF00353241
PMID:1242301
Abstract

After i.p. administration to AB mice of 405 mg/kg desmethyltrichlorphone (sodium salt) in a single dose and 54 mg/kg daily for 3 weeks, the mutagenic effect in the dominant lethal test was at least the same as that of trichlorphone. these findings indicate that the genotoxic effect of trichlorphone is not likely to be due to its alkylating properties.

摘要

以405毫克/千克的剂量向AB小鼠腹腔注射去甲基敌百虫(钠盐)单剂量,并连续3周每天注射54毫克/千克后,显性致死试验中的诱变效应至少与敌百虫相同。这些发现表明,敌百虫的遗传毒性作用不太可能归因于其烷基化特性。

相似文献

1
[The mutagenicity of desmethyltrichlorphone in dominant lethal test on mice (author's transl)].去甲基敌百虫对小鼠显性致死试验的致突变性(作者译)
Arch Toxicol. 1975 Feb 14;33(2):163-8. doi: 10.1007/BF00353241.
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[Mutagenicity of dichloroacetaldehyde and 2,2-dichloro-1,1-dihydroxy-ethanephosphonic acid methyl ester, possible metabolites of the organophosphate pesticide Trichlorphon].[敌百虫的可能代谢产物二氯乙醛和2,2-二氯-1,1-二羟基乙烷膦酸甲酯的致突变性]
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A guide for mutagenicity testing using the dominant lethal assay.使用显性致死试验进行致突变性测试的指南。
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Detection of chemical mutagens by the dominant lethal assay in the mouse.通过小鼠显性致死试验检测化学诱变剂。
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Statistical considerations for dominant lethal mutagenic trials.显性致死诱变试验的统计学考量
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Mutagenicity tests in mice. I. The dominant lethal method and the control problem.小鼠致突变性试验。I. 显性致死法及对照问题。
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[The effect of large doses of demethyltrichlorfon and ethyltrichlorfon on the embryonic development of laboratory mice].[大剂量敌百虫和敌敌畏对实验小鼠胚胎发育的影响]
Z Gesamte Hyg. 1976 Aug;22(8):565-9.

引用本文的文献

1
Metrifonate. Summary of toxicological and pharmacological information available.敌百虫。现有毒理学和药理学信息综述。
Arch Toxicol. 1978 Oct 13;41(1):3-29. doi: 10.1007/BF00351766.

本文引用的文献

1
[Mutagenic action of alkyl phosphates on T4B phage and alkylation of phage DNA].[烷基磷酸酯对T4B噬菌体的诱变作用及噬菌体DNA的烷基化]
Dokl Akad Nauk SSSR. 1971;198(6):1442-4.
2
Mutagenicity of trimethylphosphate in mice.磷酸三甲酯对小鼠的致突变性。
Science. 1970 May 1;168(3931):584-6. doi: 10.1126/science.168.3931.584.
3
Urinary excretion of methylated purines following inhalation of dimethyl sulphate.吸入硫酸二甲酯后甲基化嘌呤的尿排泄情况。
Experientia. 1974 Jun 15;30(6):641-2. doi: 10.1007/BF01921519.
4
[Valuation of the alkylating potential of phosphoric acid esters with oncological relevance by means of the NBP reaction (author's transl)].
Arch Geschwulstforsch. 1973;42(1):34-40.
5
[Demonstration of a genetic effect of organophosphorus insecticides].
Naturwissenschaften. 1973 Jan;60(1):50-1. doi: 10.1007/BF00591769.
6
The alkylating properties of organophosphates.有机磷酸酯的烷基化特性。
Xenobiotica. 1972 Jul;2(4):307-37. doi: 10.3109/00498257209111060.
7
Mutagenicity of dichlorvos.敌敌畏的致突变性。
Nature. 1972 Dec 15;240(5381):418-20. doi: 10.1038/240418a0.
8
On the mutagenic action of dichlorvos.敌敌畏的诱变作用
Mutat Res. 1972 Dec;16(4):413-6. doi: 10.1016/0027-5107(72)90210-2.
9
[Identification of alkylating agents. II. Identification of different classes of alkylating agents by a modification of the color reaction with 4-(4-nitrobenzyl)-pyridine (NBP)].
Arzneimittelforschung. 1969 Jul;19(7):1059-73.
10
[Cancerogenicity of di-isopropylsulphate (DIPS) and non-cancerogenicity of monomethysulphate in BD-rats (author's transl)].二异丙基硫酸酯(DIPS)对BD大鼠的致癌性及单甲基硫酸酯的非致癌性(作者译)
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(2):135-40. doi: 10.1007/BF00284389.