Fischer G W, Schneider P, Scheufler H
Chem Biol Interact. 1977 Nov;19(2):205-13. doi: 10.1016/0009-2797(77)90032-1.
Dichloroacetaldehyde and 2,2-dichloro-1,1-dihydroxy-ethanephosphonic acid methyl ester which are formed solvolytically from desmethyltrichlorphone, an in vivo metabolite of the organophosphorus pesticide Trichlorphone, show in the dominant lethal test in mice at equimolar dosage (1.6 mmol/kg) a mutagenic activity comparable with that of Trichlorphon. Therefore it cannot be ruled out that the genetic effects of this pesticide may be due in part to the action of its degradation products.
二氯乙醛和2,2-二氯-1,1-二羟基乙烷膦酸甲酯由有机磷农药敌百虫的体内代谢产物去甲基敌百虫通过溶剂分解形成，在小鼠显性致死试验中，等摩尔剂量（1.6 mmol/kg）时显示出与敌百虫相当的诱变活性。因此，不能排除这种农药的遗传效应可能部分归因于其降解产物的作用。
