微波辅助类肽的固相合成
Microwave-assisted solid-phase synthesis of peptoids.
作者信息
Olivos Hernando J, Alluri Prasanna G, Reddy M Muralidhar, Salony Derek, Kodadek Thomas
机构信息
Center for Biomedical Inventions, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-8573, USA.
出版信息
Org Lett. 2002 Nov 14;4(23):4057-9. doi: 10.1021/ol0267578.
PMID:12423085
Abstract
Microwave irradiation reduces the reaction time for the solid-phase synthesis of peptoids. Under these conditions, coupling of each residue requires only 1 min. The purity and yields of peptoids synthesized in this way are as good as or better than those achieved using standard methods. [reaction: see text]
摘要
微波辐射缩短了类肽固相合成的反应时间。在这些条件下，每个残基的偶联仅需1分钟。以这种方式合成的类肽的纯度和产率与使用标准方法所获得的相当或更高。[反应：见正文]
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