Kreutzberger V A, Schücker R, Schenck G
Arzneimittelforschung. 1975 May;25(5):709-11.
With a view to the cytostatic effect exhibited by certain representatives of the 2,2'-hydrazopyrimidines on the one hand, and by various drugs carrying branched substituents on the other hand, 4,4',6,6'-tetra-tert.-butyl-2,2'-hydrazopyrimidine (III) has been prepared by condensation of 1,2-hydrazine-dicarboxamidine (I) with 2,2,6,6-tetramethyl-3,5-heptanedione (II). Structure III has been confirmed by IR and NMR data and by its N,N'-diacetyl derivative IV.
鉴于一方面某些2,2'-肼基嘧啶衍生物具有细胞抑制作用，另一方面各种带有支链取代基的药物也有此作用，通过1,2-肼基二脒（I）与2,2,6,6-四甲基-3,5-庚二酮（II）缩合制备了4,4',6,6'-四叔丁基-2,2'-肼基嘧啶（III）。结构III已通过红外光谱和核磁共振数据以及其N,N'-二乙酰基衍生物IV得到证实。
