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[具有支链取代基的2,2-肼基嘧啶作为潜在的抗肿瘤剂。与肼-N,N-二甲脒的缩合反应]

[2,2-Hydrazinopyrimidines with branched substituents as potential antitumor agents. Condensation with hydrazine-N,N-dicarboxamidine].

作者信息

Kreutzberger V A, Schücker R, Schenck G

出版信息

Arzneimittelforschung. 1975 May;25(5):709-11.

PMID:1242310
Abstract

With a view to the cytostatic effect exhibited by certain representatives of the 2,2'-hydrazopyrimidines on the one hand, and by various drugs carrying branched substituents on the other hand, 4,4',6,6'-tetra-tert.-butyl-2,2'-hydrazopyrimidine (III) has been prepared by condensation of 1,2-hydrazine-dicarboxamidine (I) with 2,2,6,6-tetramethyl-3,5-heptanedione (II). Structure III has been confirmed by IR and NMR data and by its N,N'-diacetyl derivative IV.

摘要

鉴于一方面某些2,2'-肼基嘧啶衍生物具有细胞抑制作用,另一方面各种带有支链取代基的药物也有此作用,通过1,2-肼基二脒(I)与2,2,6,6-四甲基-3,5-庚二酮(II)缩合制备了4,4',6,6'-四叔丁基-2,2'-肼基嘧啶(III)。结构III已通过红外光谱和核磁共振数据以及其N,N'-二乙酰基衍生物IV得到证实。

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